The problem with pre-seed and seed biotech venture capital is that it too often underestimates great startups and invests in those destined to fail. This is because decisions are usually made by VCs having business/finance backgrounds, not by scientist-investors. We believe that the typical roles need to be reversed: scientists should make investment decisions, with support from business majors. By empowering scientists, Deep Views will change the narrative of early-stage biotech investing.

Scientists — through education and experience — are better-equipped than financiers to evaluate the key determinants of an early-stage biotech startup’s success:

  • The surmountability of scientific/technical hurdles required…

“Put simply, I hypothesize that Nektar is the subject of a short and distort scheme, kicked off by Plainview LLC’s hit piece and maintained by hedge funds employing all of the levers at their disposal, including paid message board ‘trolls,’ corrupted Wall St. ‘news’ entities and frequent manipulation of share price.”

The recent situation with GameStop (GME) has shed light on the shady practices of many institutional investors, including hedge funds. Building on that awareness, let’s examine a sector in which Wall Street manipulation is aided by the misrepresentation of scientific results: biotech. A prime example of this is the…

Progress, George Frederic Watts (1817–1904), oil on canvas. Trampled by allegorical Progress on his horse, three enemies, from left to right, are a myopic scholar reading by candlelight, a rich man scrounging for money, and a slothful man lounging.

Duke University, the school from which I received my Ph.D. in biochemistry, recently agreed to pay $112 million to settle a whistle-blower lawsuit for research misconduct. I found the settlement both unsurprising and underwhelming, a slap on the wrist for a private institution boasting an endowment of ~$8.5 billion. Falsification of publications and grant applications from the laboratory of Duke Medical School Professor William Michael Foster and his technician Erin Potts-Kant was alleged as early as 2013, but resulted in an internal investigation for which Duke buried the results (a common outcome, as I shall relate). Only a lawsuit by…

Yan Liu and Louis Metzger

“Any human power can be resisted and changed by human beings.” — Ursula K. Le Guin

Few would disagree that our political system is dysfunctional, and that this has caused great suffering and unprecedented crises, ranging from systemic social-economic injustice to global climate breakdown. It is up to us to reinvent politics and to create a better future.

1. Real change is based on shifting the Overton window.

“[Optimism is] not naive and it’s not innocent. [It’s] a moral and political position. It’s a choice made to insist that things could be better if we…

This superb article by The Atlantic, and the studies underlying it, are long overdue. Pursuing a Ph.D. is terrible for students’ mental and physical health. So long as advanced education in the sciences is run as a pyramid scheme, wherein a large underclass of graduate students and postdocs performs the tenured professors’ research, and supports a proliferation of superfluous academic administrators from the “grant overhead” that these trainees’ work earns, this problem will continue. Doctoral programs have become less about education, and more about the big business of universities harvesting grant money. Not only does this lead to a perversion…

Louis E. Metzger IV

Trying to apply systems thinking to change the culture of science/edu. Power in solidarity. #DeepTech #politics #OurTime

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